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Evolution-guided prioritization identifies a tissue-specific phosphorylation switch on herpes simplex virus 1 UL7 regulating viral replication and pathogenicity

ABSTRACT Although numerous phosphorylation sites on herpes simplex virus 1 (HSV-1) proteins have been identified through phosphoproteomic analyses, their virological significance remains largely unclear. Here, we developed an evolution-guided prioritization strategy that integrates phosphoproteomic...

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Principais autores: Akihisa Kato, Takanori Tannaka, Ryoji Iwasaki, Saori Shio, Shaocong Liu, Kousuke Takeshima, Yuhei Maruzuru, Yasushi Kawaguchi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-05-01
Serier:Journal of Virology
Fag:
evolution-guided prioritization
HSV-1
UL7
phosphorylation
pathogenicity
Online adgang:https://journals.asm.org/doi/10.1128/jvi.00200-26
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