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MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

The tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here the authors show that radiation induced miR-103 downregulates TREX1 in endothelial cells, decreases angiogenesis and leads to the secretion of proinflammatory mediators that reduce tumour growth.

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Principais autores: RaeAnna Wilson, Cristina Espinosa-Diez, Nathan Kanner, Namita Chatterjee, Rebecca Ruhl, Christina Hipfinger, Sunil J. Advani, Jie Li, Omar F. Khan, Aleksandra Franovic, Sara M. Weis, Sushil Kumar, Lisa M. Coussens, Daniel G. Anderson, Clark C. Chen, David A. Cheresh, Sudarshan Anand
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2016-11-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/ncomms13597
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