Investigation of Sonication Parameters for Large-Volume Focused Ultrasound-Mediated Blood–Brain Barrier Permeability Enhancement Using a Clinical-Prototype Hemispherical Phased Array

<b>Background/Objectives:</b> Focused ultrasound (FUS) and microbubble (MB) exposure is a promising technique for targeted drug delivery to the brain; however, refinement of protocols suitable for large-volume treatments in a clinical setting remains underexplored. <b>Methods:</b> Here, the impacts...

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Hauptverfasser:	Dallan McMahon, Ryan M. Jones, Rohan Ramdoyal, Joey Ying Xuan Zhuang, Dallas Leavitt, Kullervo Hynynen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2024-09-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	focused ultrasound microbubble blood–brain barrier infusion image-guided therapy
Online-Zugang:	https://www.mdpi.com/1999-4923/16/10/1289
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