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Molecular Modeling of ABHD5 Structure and Ligand Recognition

Alpha/beta hydrolase domain-containing 5 (ABHD5), also termed CGI-58, is the key upstream activator of adipose triglyceride lipase (ATGL), which plays an essential role in lipid metabolism and energy storage. Mutations in ABHD5 disrupt lipolysis and are known to cause the Chanarin-Dorfman syndrome....

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Main Authors: Rezvan Shahoei, Susheel Pangeni, Matthew A. Sanders, Huamei Zhang, Ljiljana Mladenovic-Lucas, William R. Roush, Geoff Halvorsen, Christopher V. Kelly, James G. Granneman, Yu-ming M. Huang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
molecular dynamics
docking
structural modeling
ABHD5
lipid droplet
AlphaFold
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.935375/full
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