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Protein Misfolding and Aggregation as a Therapeutic Target for Polyglutamine Diseases

The polyglutamine (polyQ) diseases, such as Huntington’s disease and several types of spinocerebellar ataxias, are a group of inherited neurodegenerative diseases that are caused by an abnormal expansion of the polyQ tract in disease-causative proteins. Proteins with an abnormally expanded polyQ str...

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Principais autores: Toshihide Takeuchi, Yoshitaka Nagai
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2017-10-01
coleção:Brain Sciences
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Acesso em linha:https://www.mdpi.com/2076-3425/7/10/128
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