The gut microbiota–brain–CAR T cell axis: a systematic review of gut microbiome modulation and its impact on neurological complications and treatment responses in CAR T cell therapy

BackgroundCAR T-cell therapy represents a substantial advance for relapsed/refractory hematologic cancers, but toxicities still limit its benefits. A particular concern is immune effector cell–associated neurotoxicity syndrome (ICANS), whose mechanisms remain only partly resolved. In parallel, work...

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Autors principals:	Ashvath Arumugam Pillai, Sai K. Reddy Pasya, Gaurav Kansal, Aishwarya Jaikrishnan, Anchit Chauhan, Arghadip Das, Korat Parth Manojbhai, V. Deepak Prabu, Muhammad Mahdi Nashatizadeh
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-01-01
Col·lecció:	Frontiers in Immunology
Matèries:	CAR T-cell therapy gut microbiota ICANS neurotoxicity microbiome immunotherapy
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1703146/full
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