Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity

Leucine-rich repeat kinase 2 (LRRK2) is involved in Parkinson’s disease (PD) pathology. A previous study showed that rotenone treatment induced apoptosis, mitochondrial damage, and nucleolar disruption via up-regulated LRRK2 kinase activity, and these effects were rescued by an LRRK2 kinase inhibito...

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Hlavní autoři:	Jihoon Jang, Hakjin Oh, Daleum Nam, Wongi Seol, Mi Kyoung Seo, Sung Woo Park, Hyung Gun Kim, Hyemyung Seo, Ilhong Son, Dong Hwan Ho
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2018-09-01
Edice:	Animal Cells and Systems
Témata:	Parkinson’s disease rotenone leucine-rich repeat kinase 2 (LRRK2) nucleolin heat shock protein 70
On-line přístup:	http://dx.doi.org/10.1080/19768354.2018.1518262
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