The E3 ubiquitin ligase NEDD4 regulates chemoresistance to 5-fluorouracil in colorectal cancer cells by altering JNK signalling

Abstract Colorectal cancer (CRC) is the second leading cause of cancer deaths. Though chemotherapy is the main treatment option for advanced CRC, patients invariably acquire resistance to chemotherapeutic drugs and fail to respond to the therapy. Although understanding the mechanisms regulating chem...

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Autores principales:	Sushma Anand, Christina Nedeva, Sai V. Chitti, Pamali Fonseka, Taeyoung Kang, Lahiru Gangoda, Nishat I. Tabassum, Suad Abdirahman, Thiruma V. Arumugam, Tracy L. Putoczki, Sharad Kumar, Suresh Mathivanan
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 2023-12-01
Colección:	Cell Death and Disease
Acceso en línea:	https://doi.org/10.1038/s41419-023-06349-z
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