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Pharmacokinetics and Pharmacodynamics of Rusfertide, a Hepcidin Mimetic, Following Subcutaneous Administration of a Lyophilized Powder Formulation in Healthy Volunteers

Abstract Background and Objective Hepcidin, an endogenous peptide hormone, binds to ferroportin and is the master regulator of iron trafficking. Rusfertide, a synthetic peptide, is a potent hepcidin mimetic. Clinical studies suggest rusfertide may be effective in the treatment of polycythemia vera....

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Autores principales: Nishit B. Modi, Sarita Khanna, Sneha Rudraraju, Frank Valone
Formato: Artigo
Lenguaje:Inglês
Publicado: Adis, Springer Healthcare 2024-11-01
Colección:Drugs in R&D
Acceso en línea:https://doi.org/10.1007/s40268-024-00497-z
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