Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ

Abstract Background Aberrant overexpression of PIWI/piRNA pathway proteins is shown for many types of tumors. Interestingly, these proteins are downregulated in testicular germ cell tumors (TGCTs) compared to normal testis tissues. Here, we used germline and TGCT markers to assess the piRNA biogenes...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Ildar V. Gainetdinov, Yulia V. Skvortsova, Sofia A. Kondratieva, Alexey Klimov, Alexey A. Tryakin, Tatyana L. Azhikina
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-01-01
coleção:	BMC Cancer
Assuntos:	PIWI piRNA Testicular germ cell tumor Seminoma Nonseminoma GCNIS
Acesso em linha:	http://link.springer.com/article/10.1186/s12885-017-3945-6
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!