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Impurity study of tecovirimat

This article delineates the systematic identification, synthesis, and impurity control methods used during the manufacturing process development of tecovirimat, an antiviral drug that treats monkeypox. Critical impurities were synthesized, and their chemical structure was confirmed through NMR analy...

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Main Authors: Emmanuel Mintah Bonku, Hongjian Qin, Abdullajon Odilov, Safomuddin Abduahadi, Samuel Desta Guma, Feipu Yang, Xinglong Xing, Xukun Wang, Jingshan Shen
Format: Artigo
Language:Inglês
Published: Elsevier 2024-05-01
Series:Heliyon
Subjects:
Tecovirimat
Genotoxic impurities
Process development
International Conference on Harmonization (ICH)
Quality control
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024055907
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