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Prognosis of ALK-rearranged non-small-cell lung cancer patients carrying TP53 mutations

Non-small-cell lung cancer (NSCLC) is the primary cause of cancer-related death. Gene rearrangements involving the anaplastic lymphoma kinase (ALK) tyrosine kinase identify a clinical and molecular subset of NSCLC patients, who benefit from the monotherapy with ALK tyrosine kinase inhibitors. Noneth...

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Principais autores: Matteo Canale, Elisabetta Petracci, Paola Cravero, Marita Mariotti, Gabriele Minuti, Giulio Metro, Vienna Ludovini, Sara Baglivo, Maurizio Puccetti, Alessandra Dubini, Giovanni Martinelli, Angelo Delmonte, Lucio Crinò, Paola Ulivi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-09-01
coleção:Translational Oncology
Assuntos:
Non-small cell lung cancer (NSCLC)
Anaplastic lymphoma kinase (ALK) gene re-arrangements
Tumor protein 53 (TP53) gene mutations
Prognosis
Therapy resistance
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1936523322001309
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