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Molecular Mechanisms and Therapeutic Targeting of Ferroptosis in Doxorubicin-Induced Cardiotoxicity

Summary: Ferroptosis, an iron-dependent form of regulated cell death, has received increasing attention for its pathophysiologic contribution to the onset and development of doxorubicin-induced cardiotoxicity. Moreover, modulation of ferroptosis with specific inhibitors may provide new therapeutic o...

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Principais autores: Lin Wu, MD, Yingmei Zhang, MD, PhD, Guizhen Wang, MD, Jun Ren, MD, PhD
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-06-01
coleção:JACC: Basic to Translational Science
Assuntos:
cardiotoxicity
doxorubicin
ferroptosis
iron
glutathione metabolism
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2452302X23004928
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