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Electrophysiological Characterization of the Venom and Toxins from the Scorpion <i>Tityus championi</i> Targeting Voltage-Gated Sodium Channels and Molecular Modeling of Tch3, a Toxin with Therapeutic Potential for Pain Relief

Scorpion neurotoxins are small peptides that target ion channels and offer opportunities for novel therapeutic discovery. This study analyzed the functional effects of the venom and toxins from the Costa Rican endemic scorpion, <i>Tityus championi</i>. Initially, crude venom was tested on different...

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Main Authors: Galit Akerman-Sánchez, Steve Peigneur, Kathleen Carleer, Natalia Ortiz, Felipe Navia, Leonardo Fierro, Santiago Castaño, Cecilia Díaz, Jan Tytgat, Oscar Brenes
Format: Artigo
Language:Inglês
Published: MDPI AG 2026-04-01
Series:Biomolecules
Subjects:
<i>Tityus</i>
buthidae
scorpion venom
voltage-gated sodium channels
oocytes
invertebrate neurons
Online Access:https://www.mdpi.com/2218-273X/16/4/552
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