Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma

Abstract Glioblastoma (GBM) is an incurable brain tumor characterized by high heterogeneity. Oncolytic viruses (OVs) are an approved therapy, but their efficacy is often limited by poor cellular permissiveness to infection. Here we screen bioactive compounds to identify enhancers of oncolytic herpes...

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Autori principali:	Yaning Qin, Zhiqi Liang, Mengqin Yu, Nanqian Lin, Naizhen Wang, Xuanke Huang, Shi Chen, Qun Peng, Yanhua Lin, Heqin Wang, Yipeng Rao, Zilong Xu, Shenghua Huang, Jingjing Cai, Yukui Li, Jun Zhang, Chaolong Lin, Guowei Tan, Ningshao Xia, Chenghao Huang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-02-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-026-70132-9
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