Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators

Abstract Background Dystrophin deficiency sensitizes skeletal muscle of mice to eccentric contraction (ECC)-induced strength loss. ECC protocols distinguish dystrophin-deficient from healthy, wild type muscle, and test the efficacy of therapeutics for Duchenne muscular dystrophy (DMD). However, give...

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Detalhes bibliográficos

Principais autores:	Angus Lindsay, Cory W. Baumann, Robyn T. Rebbeck, Samantha L. Yuen, William M. Southern, James S. Hodges, Razvan L. Cornea, David D. Thomas, James M. Ervasti, Dawn A. Lowe
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2020-02-01
coleção:	Skeletal Muscle
Assuntos:	Dystrophin Eccentric contraction Force drop Muscle damage Oxidative stress Ryanodine receptor
Acesso em linha:	https://doi.org/10.1186/s13395-020-0221-2
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