Metformin alleviates anti-oxidant and anti-apoptotic effects by regulating the Nrf2/HO-1 signaling pathway in a rat model of testicular ischemia/reperfusion

Objective(s): This study aimed to investigate the effect of metformin on testicular ischemia-reperfusion (I/R) injury in rats. Materials and Methods: Eighteen male SD rats were randomly divided into three groups: Sham group, I/R group, and Metformin (Met) group (n=6 per group). The I/R model was est...

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Detalhes bibliográficos

Principais autores:	Zhi-Mei Li, Ren-Yuan Chang, Rui Li, Jing-Bao Wang, Ai-Ling Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Mashhad University of Medical Sciences 2026-03-01
coleção:	Iranian Journal of Basic Medical Sciences
Assuntos:	anti-apoptotic anti-oxidant heme oxygenase - 1 ischemia reperfusion injury kelch-like ech-associated- protein 1 metformin nf-e2-related factor 2
Acesso em linha:	https://ijbms.mums.ac.ir/article_27342_c2245304925a42b6597c0a08e21723ab.pdf
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