In vitro, ex vivo, and in vivo evaluation of ophthalmic ointments containing dexamethasone and tobramycin

This investigation compares in vitro release, ex vivo release and permeation, and in vivo ocular pharmacokinetics to render biologically informed evaluations of ophthalmic semi-solid drug products containing dexamethasone (hydrophobic) and tobramycin (hydrophilic). Both drugs were formulated with th...

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Principais autores:	Catheleeya Mekjaruskul, Andre O'Reilly Beringhs, Tuo Meng, Aji Alex Moothedathu Raynold, Qingguo Xu, Matthew Halquist, Bin Qin, Yan Wang, Xiuling Lu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2026-06-01
Series:	International Journal of Pharmaceutics: X
Assuntos:	Ophthalmic ointment In vitro release test Ex vivo ocular permeation In vivo ocular pharmacokinetics Dexamethasone Tobramycin
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2590156725001616
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