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Generation of a symmetrical trispecific NK cell engager based on a two-in-one antibody

To construct a trispecific IgG-like antibody at least three different binding moieties need to be combined, which results in a complex architecture and challenging production of these molecules. Here we report for the first time the construction of trispecific natural killer cell engagers based on a...

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Principais autores: Julia Harwardt, Stefania C. Carrara, Jan P. Bogen, Katrin Schoenfeld, Julius Grzeschik, Björn Hock, Harald Kolmar
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2023-04-01
叢編:Frontiers in Immunology
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在線閱讀:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170042/full
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