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PD-L1 autoregulation promotes the proliferation, migration and invasion of glioblastoma cells via GP130/JAK2/STAT3/IRAK2/IL6 signaling pathway

Abstract Glioblastoma (GBM) cells mediate immunosuppressive microenvironment, leading to poor response to programmed death-ligand 1(PD-L1) inhibitor therapy. How PD-L1 in GBM cells confers to GBM immunosuppressive microenvironment remains unclear. Here, we demonstrate that PD-L1 activated GP130/JAK2...

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Principais autores: Xin Xie, Jingdi Bai, Yuhui Peng, Pingping Chen, Zhuxue Zhang, Daogui Fan, Feng Zhou, Yuan Yuan, Jiyun Liu, Yu Zhou, Qin Hong, Jianjun Hu, Juanjuan Duan, Wenli Fu, Ting Zhang, Hongmei Zeng, Jie Deng, Yangting Dong, Ying Liu, Xiaolan Qi, Wei Hong, Yan He, Chunlin Zhang, Wenfeng Yu, Qintian Yang, Wei Yi, Hua Bai, Qifang Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-10-01
Serier:Scientific Reports
Fag:
Glioblastoma
PD-L1
GP130
STAT3
IRAK2
IL6
Online adgang:https://doi.org/10.1038/s41598-025-19169-2
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