N-isopropyl-(4-methoxy-3-difluoromethyl)cinnamoyl amide targets mycobacterial MmpL3

Mycobacterial infections still need new and more efficient drugs. In the present work we developed a new and simpler protocol for the synthesis of N-isopropyl-(4-methoxy-3-difluoromethyl)cinnamoyl amide, here named as 3M99F1, a promising candidate for mycobacterial growth inhibition. Using whole gen...

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Auteurs principaux:	Mario D. Martínez, Liliana Rondón, Lisandro Ronconi, Mariano Prado Acosta, Agostina Crotta Asis, Gabriela Gago, Florencia Di Salvo, Gerardo Burton, Fernando Durán, Mariana Piuri
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2024-12-01
Collection:	European Journal of Medicinal Chemistry Reports
Sujets:	Mycobacteria MmpL3 Difluoromethylcinnamoyl amides
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2772417424000608
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