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Trapidil attenuates diabetic cardiomyopathy via GPX3/Nrf2-mediated inhibition of myocardial pyroptosis

BackgroundCurrently, there is a paucity of clinically effective medications for the treatment of diabetic cardiomyopathy (DCM), while the strategy of drug repurposing offers a promising avenue for advancing therapeutic development.MethodsThe investigation explored the ameliorative effects and uncove...

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Principais autores: Zihao Wang, Yingzi Sun, Juanjuan Wang, Qiuyue Xu, Liuxing Wang, Qi Zhang, Juan Song, Yuchun Wang, Zhanpeng Qi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-06-01
coleção:Frontiers in Pharmacology
Assuntos:
diabetic cardiomyopathy
pyroptosis
trapidil
GPX3
Nrf2
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2025.1566622/full
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