Increasing Human Neural Stem Cell Transplantation Dose Alters Oligodendroglial and Neuronal Differentiation after Spinal Cord Injury

Multipotent human central nervous system-derived neural stem cells transplanted at doses ranging from 10,000 (low) to 500,000 (very high) cells differentiated predominantly into the oligodendroglial lineage. However, while the number of engrafted cells increased linearly in relationship to increasin...

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Hlavní autoři: Katja M. Piltti, Gabriella M. Funes, Sabrina N. Avakian, Ara A. Salibian, Kevin I. Huang, Krystal Carta, Noriko Kamei, Lisa A. Flanagan, Edwin S. Monuki, Nobuko Uchida, Brian J. Cummings, Aileen J. Anderson
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017-06-01
Edice:Stem Cell Reports
Témata:
human neural stem cell
spinal cord injury
stem cell niche dynamics
stem cell transplantation
cell dose
differentiation
fate
migration
microenvironment
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2213671117301637
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