Hierarchical chirality of bone cement drives osteoinduction via integrin dependent signaling to accelerate critical bone defect regeneration

Abstract The biocompatibility and degradability of calcium phosphate bone cement (CPC) make it a potential therapeutic strategy to critical bone defects repair. However, it fails to create a stable extracellular microenvironment for inducing stem cells osteogenic differentiation, which hinders the w...

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Detalles Bibliográficos

Principais autores:	Jinzhou Du, Liang Yang, Lingchi Kong, Tengfei Lou, Ai Yang, Chao Zhou, Yun Qian, Cunyi Fan
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-12-01
Series:	Journal of Nanobiotechnology
Assuntos:	Osteoinductivity Hydroxyapatite Chirality Critical bone defect repair Bone marrow mesenchymal stem cell
Acceso en liña:	https://doi.org/10.1186/s12951-025-03826-9
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