High glucose-induced PLCG1 histone acetylation to promote ferroptosis by LAMP2A/HSPA8 in a diabetic nephropathy model

Diabetic nephropathy (DN) is one of the most prevalent microvascular complications of diabetes mellitus. In the present study, the effects of PLCG1 DN, as well as its underlying molecular mechanisms associated with ferroptosis, were investigated. Single-cell RNA sequencing data and bioinformatic ana...

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Detalhes bibliográficos

Principais autores:	Jun Ge, Zhenzhen Wang, Ting Xu, Ruifeng Jiang, Xuefeng Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-01-01
coleção:	Frontiers in Pharmacology
Assuntos:	diabetic nephropathy PLCG1 histone acetylation ferroptosis treatment
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1640721/full
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