Immuno-radiotherapy enhances tumor control and induces abscopal responses in a humanized mouse model

IntroductionRadiation therapy (RT) offers a tool to enhance immune checkpoint inhibitor (ICI) efficacy, yet its immunomodulatory potential remains poorly understood. Here, we investigated how RT dose-fractionation regimens shape local and systemic antitumor immunity.MethodsA hematopoietic stem cell-...

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Autori principali:	Morgane M. Cogels, Matteo Serra, Hugues Duvillier, Soizic Garaud, Laurine Verset, David Venet, Chrysanthi Iliadi, Tycho de Bakker, Laurence Buisseret, Redouane Rouas, Christos Sotiriou, Françoise Rothé, Alex de Caluwé, Dirk Van Gestel, Sébastien Penninckx
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-03-01
Serie:	Frontiers in Immunology
Soggetti:	immunotherapy radiotherapy humanized mice abscopal effect tumor immune microenvironment.
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1774955/full
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