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Interactions among Polycomb domains are guided by chromosome architecture.

Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes. Here, we adapted the Chromosome Conformation Capture on Chip (4C) assay to systematically map chromosomal in...

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Bibliografiske detaljer
Principais autores: Bas Tolhuis, Marleen Blom, Ron M Kerkhoven, Ludo Pagie, Hans Teunissen, Marja Nieuwland, Marieke Simonis, Wouter de Laat, Maarten van Lohuizen, Bas van Steensel
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2011-03-01
Serier:PLoS Genetics
Online adgang:http://europepmc.org/articles/PMC3063757?pdf=render
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