Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity

TEM-1 β-lactamase evolved from ancestral enzymes that degraded a variety of β-lactam antibiotics with moderate efficiency and degrades β-lactam antibiotics with a strong preference for penicillins. Here authors developed a computational approach to rationally mold a protein flexibility profile on th...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Tushar Modi, Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, Mubark D. Mebrat, Wade D. Van Horn, Jose M. Sanchez-Ruiz, S. Banu Ozkan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2021-03-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-021-22089-0
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!