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MCD enzyme deficiency drives early mortality and multiorgan metabolic disruption in Dahl salt-sensitive rats

Summary: Malonyl-CoA decarboxylase (MCD), encoded by Mlycd, plays a critical role in regulating malonyl-CoA levels, fatty acid oxidation, and glucose metabolism. To investigate the systemic effects of Mlycd deficiency, we generated a genetically modified rat model with partial loss of Mlycd. Due to...

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Principais autores: Olha Kravtsova, Yifan Tan, Vladislav Levchenko, Elina Kovalenko, Ratnakar Tiwari, Adrian Zietara, Ruslan Bohovyk, Lashodya V. Dissanayake, Thanh Trung Van, Thomas E. Sharp, III, Aron M. Geurts, Oleg Palygin, Markus M. Rinschen, Alexander Staruschenko
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-01-01
Serier:iScience
Fag:
Proteomics
Metabolomics
Online adgang:http://www.sciencedirect.com/science/article/pii/S258900422502766X
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