Horse-Derived Ceramide Accentuates Glucosylceramide Synthase and Ceramide Synthase 3 by Activating PPARβ/δ and/or PPARγ to Stimulate Ceramide Synthesis

Horse-derived ceramide (HC), which contains galactosylceramides as its main component, significantly improves skin symptoms when applied topically to patients with atopic dermatitis. We speculated that efficacy resulted from the amelioration of epidermal ceramide metabolism, and we characterized tho...

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Autores principales:	Tami Igarashi, Hiroki Yanagi, Masayuki Yagi, Masamitsu Ichihashi, Genji Imokawa
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2023-02-01
Colección:	Biomedicines
Materias:	horse-derived ceramide galactosylceramide ceramide synthase 3 fatty acid elongase 4 glucosylceramide synthase β-glucocerebrosidase
Acceso en línea:	https://www.mdpi.com/2227-9059/11/2/548
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