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Increased TGFβ1 and SMAD3 Contribute to Age-Related Aortic Valve Calcification

AimsCalcific aortic valve disease (CAVD) is a progressive heart disease that is particularly prevalent in elderly patients. The current treatment of CAVD is surgical valve replacement, but this is not a permanent solution, and it is very challenging for elderly patients. Thus, a pharmacological inte...

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Furkejuvvon:
Váldodahkkit: Mrinmay Chakrabarti, Aniket Bhattacharya, Mengistu G. Gebere, John Johnson, Zeeshan A. Ayub, Ioulia Chatzistamou, Narendra R. Vyavahare, Mohamad Azhar
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2022-07-01
Ráidu:Frontiers in Cardiovascular Medicine
Fáttát:
Tgfb = transforming growth factor beta
Smad3
Klotho
CAVD (calcific aortic valve disease)
aortic valve calcification
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fcvm.2022.770065/full
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