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YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses

ABSTRACT Chikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as an essential cellular factor for CHIKV. Deficiency...

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Hlavní autoři: Zhen-Qi Li, Li-Xin Zhao, Su-Yun Wang, Chu-Yu Hu, Yan-Yi Wang, Yan Yang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2025-02-01
Edice:Journal of Virology
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On-line přístup:https://journals.asm.org/doi/10.1128/jvi.02015-24
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