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The fading guardian: clinical relevance of TP53 null mutation in high-grade serous ovarian cancers

Backgroundwe evaluated the concordance between immunohistochemical p53 staining and TP53 mutations in a series of HGSOC. Moreover, we searched for prognostic differences between p53 overexpression and null expression groups.Methodspatients affected by HGSOC were included. For each case p53 immunohis...

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Autori principali: Chiara M. Biatta, Michele Paudice, Marco Greppi, Veronica Parrella, Alessia Parodi, Giuseppa De Luca, Gianna Maria Cerruti, Serafina Mammoliti, Cinzia Caroti, Paola Menichini, Gilberto Fronza, Silvia Pesce, Emanuela Marcenaro, Valerio G. Vellone
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2023-08-01
Serie:Frontiers in Immunology
Soggetti:
high grade serous ovarian carcinoma
TP53
immunohistochemistry
sanger sequencing
ovarian cancer
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1221605/full
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