Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic

Abstract Background Modern designs for dose-finding studies (e.g., model-based designs such as continual reassessment method) have been shown to substantially improve the ability to determine a suitable dose for efficacy testing when compared to traditional designs such as the 3 + 3 design. However,...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Sean Ewings, Geoff Saunders, Thomas Jaki, Pavel Mozgunov
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2022-01-01
Schriftenreihe:	BMC Medical Research Methodology
Schlagworte:	Bayesian Phase I Adaptive design Dose escalation
Online-Zugang:	https://doi.org/10.1186/s12874-022-01512-0
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