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Small peptide P110 mitigates axonal degeneration of SPG15 patient iPSC-derived neurons by targeting mitochondrial dysfunction

Hereditary Spastic Paraplegias (HSPs) are a group of heterogeneous neurological diseases characterized by axonal degeneration of corticospinal motor neurons. SPG15, a common autosomal recessive form of HSP, is caused by mutations in the ZFYVE26 gene that encodes the spastizin protein. Spastizin part...

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Principais autores: Bavavarshini Tamilselvam, Gitika Thakur, Ruth Mathew, Eric Chai, Jose Lopez, Zhenyu Chen, Weihai Zhan, Craig Blackstone, Xue-Jun Li
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2025-12-01
סדרה:Neurobiology of Disease
נושאים:
Hereditary spastic paraplegias
SPG15
Axonal degeneration
Mitochondrial dysfunction
Apoptosis
iPSCs
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S0969996125003912
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