Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response

Monomethyl fumarate (MMF), metabolite of dimethyl fumarate (DMF), an immunosuppressive drug approved for the treatment of multiple sclerosis (MS), is a potent agonist for hydroxycarboxylic acid receptor 2 (HCAR2), eliciting signals that dampen cell activation or lead to inflammation such as the skin...

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Principais autores:	Benedetta Parodi, Alessia Sanna, Alessia Cedola, Antonio Uccelli, Nicole Kerlero de Rosbo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-05-01
coleção:	Frontiers in Immunology
Assuntos:	multiple sclerosis dimethyl fumarate hydroxycarboxylic acid receptor 2 experimental autoimmune encephalomyelitis dendritic cells intestinal epithelial cells
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.655212/full
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