Large sample size and nonlinear sparse models outline epistatic effects in inflammatory bowel disease
Abstract Background Despite clear evidence of nonlinear interactions in the molecular architecture of polygenic diseases, linear models have so far appeared optimal in genotype-to-phenotype modeling. A key bottleneck for such modeling is that genetic data intrinsically suffers from underdeterminatio...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2023-10-01
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| Colecção: | Genome Biology |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s13059-023-03064-y |
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