SPOP and HAUSP bidirectionally regulate LZTS2 ubiquitination to modulate the Wnt pathway
Abstract Colorectal cancer (CRC) is a highly deadly disease worldwide, often characterized by the overactivation of the Wnt pathway. LZTS2 is known to be a tumor suppressor by negatively regulating the Wnt pathway in CRC. However, the mechanisms that control the stability of LZTS2 are not fully unde...
Gardado en:
| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2025-12-01
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| Series: | Cell Death and Disease |
| Acceso en liña: | https://doi.org/10.1038/s41419-025-08351-z |
| Tags: |
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