Genome-wide methylomic and transcriptomic analyses identify subtype-specific epigenetic signatures commonly dysregulated in glioma stem cells and glioblastoma

Glioma stem cells (GSCs), a subpopulation of tumor cells, contribute to tumor heterogeneity and therapy resistance. Gene expression profiling classified glioblastoma (GBM) and GSCs into four transcriptomically-defined subtypes. Here, we determined the DNA methylation signatures in transcriptomically...

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Egile Nagusiak:	Rajendra P. Pangeni, Zhou Zhang, Angel A. Alvarez, Xuechao Wan, Namratha Sastry, Songjian Lu, Taiping Shi, Tianzhi Huang, Charles X. Lei, C. David James, John A. Kessler, Cameron W. Brennan, Ichiro Nakano, Xinghua Lu, Bo Hu, Wei Zhang, Shi-Yuan Cheng
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Taylor & Francis Group 2018-04-01
Saila:	Epigenetics
Gaiak:	glioma stem-like cells (gsc) glioblastoma (gbm) dna methylation transcriptome signatures prognostic accuracy
Sarrera elektronikoa:	http://dx.doi.org/10.1080/15592294.2018.1469892
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