SVCT2 Overexpression and Ascorbic Acid Uptake Increase Cortical Neuron Differentiation, Which Is Dependent on Vitamin C Recycling between Neurons and Astrocytes

During brain development, sodium–vitamin C transporter (SVCT2) has been detected primarily in radial glial cells in situ, with low-to-absent expression in cerebral cortex neuroblasts. However, strong SVCT2 expression is observed during the first postnatal days, resulting in increased intracellular c...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Katterine Salazar, Francisca Espinoza, Gustavo Cerda-Gallardo, Luciano Ferrada, Rocío Magdalena, Eder Ramírez, Viviana Ulloa, Natalia Saldivia, Ninoschka Troncoso, María José Oviedo, María José Barahona, Fernando Martínez, Francisco Nualart
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-09-01
Schriftenreihe:	Antioxidants
Schlagworte:	SVCT2 vitamin C ascorbic acid dehydroascorbic acid cortical neurons neurospheres
Online-Zugang:	https://www.mdpi.com/2076-3921/10/9/1413
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