Role of farnesoid X receptor in establishment of ontogeny of phase-I drug metabolizing enzyme genes in mouse liver

The expression of phase-I drug metabolizing enzymes in liver changes dramatically during postnatal liver maturation. Farnesoid X receptor (FXR) is critical for bile acid and lipid homeostasis in liver. However, the role of FXR in regulating ontogeny of phase-I drug metabolizing genes is not clear. H...

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Ngā kaituhi matua:	Lai Peng, Stephanie Piekos, Grace L. Guo, Xiao-bo Zhong
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2016-09-01
Rangatū:	Acta Pharmaceutica Sinica B
Ngā marau:	Drug metabolizing enzymes Farnesoid X receptor Liver Ontogeny Fxr-null mouse Gene expression
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2211383516301551
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