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Retrovirus insertions in host transcripts trigger de novo piRNA immunity

Abstract How host organisms adapt their defense systems to newly invading transposable elements remains poorly understood. Here, we show how Drosophila melanogaster acquired PIWI-interacting RNA (piRNA)-mediated immunity against the endogenous retrovirus Tirant. We uncover two distinct modes of de n...

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Váldodahkkit: Baptiste Rafanel, Liudmila Protsenko, Dominik Handler, Julius Brennecke, Kirsten-André Senti
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Springer Nature 2026-05-01
Ráidu:The EMBO Journal
Liŋkkat:https://doi.org/10.1038/s44318-026-00777-1
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