Anti-TNF-α antisense-oligonucleotide-conjugated PLG nanoparticles protect transplanted islets

One of the many challenges for islet transplantation as a treatment for type 1 diabetes is inflammation that contributes to islet de-differentiation and death. Innate immune cells such as monocytes and macrophages secrete tumor necrosis factor alpha (TNF-α), interleukin 1β (IL-1β), inducible nitric...

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Bibliografiske detaljer

Principais autores:	Elizabeth J. Bealer, Namit Padgaonkar, Kelly Crumley, Eiji Saito, Zoe Beekman, Alexa DeKorte, Thazha P. Prakash, Alexey Revenko, Lonnie D. Shea
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2025-06-01
Serier:	Molecular Therapy: Methods & Clinical Development
Fag:	antisense oligonucleotide TNF-α SC islets inflammation cell transplant
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2329050125000841
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