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Quantitative sensing and signalling of single-stranded DNA during the DNA damage response

DNA damage triggers checkpoint signalling mechanisms. Here the authors reveal differential phosphorylation of targets of the Mec1-Ddc2 checkpoint kinase by analyzing the effect of quantitatively different ssDNA signals.

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Bibliografische Detailangaben
Hauptverfasser: Susanne C. S. Bantele, Michael Lisby, Boris Pfander
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2019-02-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-019-08889-5
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