Dyslipidemia-associated atherogenic oxidized lipids induce platelet hyperactivity through phospholipase Cγ2-dependent reactive oxygen species generation

Oxidized low-density lipoprotein (oxLDL) and associated oxidized phosphocholine-headgroup phospholipids (oxPCs) activate blood platelets through ligation of the scavenger receptor CD36. Previously, we found that oxLDL stimulated phosphorylation of phospholipase Cγ2 (PLCγ2). However, the functional r...

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Detalhes bibliográficos

Principais autores:	Martin Berger, Katie Wraith, Casey Woodward, Ahmed Aburima, Zaher Raslan, Matthew S. Hindle, Julia Moellmann, Maria Febbraio, Khalid M. Naseem
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2019-05-01
coleção:	Platelets
Assuntos:	oxldl oxpccd36 platelet hyperactivity plcγ2 reactive oxygen species
Acesso em linha:	http://dx.doi.org/10.1080/09537104.2018.1466386
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