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Epistasis: obstacle or advantage for mapping complex traits?

Identification of genetic loci in complex traits has focused largely on one-dimensional genome scans to search for associations between single markers and the phenotype. There is mounting evidence that locus interactions, or epistasis, are a crucial component of the genetic architecture of biologica...

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Autori principali: Koen J F Verhoeven, George Casella, Lauren M McIntyre
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2010-08-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC2928725?pdf=render
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