Thymic epithelial cell fate and potency in early organogenesis assessed by single cell transcriptional and functional analysis

During development, cortical (c) and medullary (m) thymic epithelial cells (TEC) arise from the third pharyngeal pouch endoderm. Current models suggest that within the thymic primordium most TEC exist in a bipotent/common thymic epithelial progenitor cell (TEPC) state able to generate both cTEC and...

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Principais autores:	Alison Mary Farley, An Chengrui, Sam Palmer, Dong Liu, Anastasia I. Kousa, Paul Rouse, Viktoria Major, Joanna Sweetman, Jan Morys, Andrea Corsinotti, Jennifer Nichols, Janice Ure, Renee McLay, Luke Boulter, S. Jon Chapman, Simon R. Tomlinson, C. Clare Blackburn
格式:	Artigo
语言:	Inglês
出版:	Frontiers Media S.A. 2023-07-01
丛编:	Frontiers in Immunology
主题:	thymus epithelial cells cell fate single cell transcriptome potency
在线阅读:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1202163/full
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