Managing Aminotransferase Elevations in Patients with Friedreich Ataxia Treated with Omaveloxolone: A Review and Expert Opinion on Use Considerations

Abstract Omaveloxolone is approved for the treatment of Friedreich ataxia (FA) in patients aged ≥ 16 years and is under clinical development for pediatric patients. In the MOXIe study, alanine and aspartate aminotransferase (ALT and AST) elevations were among the most common treatment-emergent adver...

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Auteurs principaux:	Susan Perlman, Mathieu Anheim, Sylvia Boesch, James H. Lewis, David R. Lynch
Format:	Artigo
Langue:	Inglês
Publié:	Adis, Springer Healthcare 2025-06-01
Collection:	Neurology and Therapy
Sujets:	Alanine aminotransferase (ALT) Aspartate aminotransferase (AST) Drug-induced liver injury (DILI) Friedreich ataxia Liver function test Nuclear factor-erythroid 2-related factor 2 (Nrf2)
Accès en ligne:	https://doi.org/10.1007/s40120-025-00752-8
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