TGF-β and IL-12 conversely orchestrate the formation of CD103+ CD8 tumor-resident memory T cells to regulate response to therapeutic cancer vaccine

Summary: The accumulation of CD103+ CD8 tumor-resident memory T (TRM) cells is predictive of response to cancer immunotherapy. Here, we show that a therapeutic peptide vaccine controls tumor growth in wild-type mice, but not in CD103-knockout mice. CD8 tumor-infiltrating T lymphocytes include two ma...

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Huvudupphovsmän: Stéphanie Corgnac, Isabelle Damei, Chiara Gentile, Aziza Caidi, Séverine Badel, Mélanie Phayanouvong, Fathia Mami-Chouaib
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2025-08-01
Serie:iScience
Ämnen:
Microenvironment
Immune response
Cancer
Länkar:http://www.sciencedirect.com/science/article/pii/S2589004225014087
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