Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction

Abstract Aims Murine models implicate phosphodiesterase 9A (PDE9A) as a nitric oxide‐independent regulator of cyclic guanosine monophosphate and promising novel therapeutic target in heart failure (HF) with preserved ejection fraction (HFpEF). This study describes PDE9A expression in endomyocardial...

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Hlavní autoři:	Christian Besler, Karl‐Philipp Rommel, Karl‐Patrik Kresoja, Justus Mörbitz, Holger Kirsten, Markus Scholz, Karin Klingel, Joachim Thiery, Ralph Burkhardt, Petra Büttner, Volker Adams, Holger Thiele, Philipp Lurz
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 2021-06-01
Edice:	ESC Heart Failure
Témata:	Phosphodiesterase 9A Heart failure Heart failure with preserved ejection fraction Fibrosis Inflammation
On-line přístup:	https://doi.org/10.1002/ehf2.13327
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